24/11/2021 - 17:00 - 18:10
COC 50 - EVOLUÇÃO DA PANDEMIA POR COVID-19 EM DIFERENTES CONTEXTOS |
37772 - LONG-TERM DURATION OF ANTIBODY RESPONSE TO SARS COV-2 IN ARGENTINIAN SLUM
VANINA PAGOTTO - HOSPITAL ITALIANO DE BUENOS AIRES, LORENA LUNA - MINISTRY OF HEALTH, JULIETA SALTO - MINISTRY OF HEALTH, MAGDALENA WAGNER MANSLAU - MINISTRY OF HEALTH, SILVANA FIGAR - HOSPITAL ITALIANO DE BUENOS AIRES, ALICIA S. MISTCHENKO - HOSPITAL DE NIñOS RICARDO GUTIÉRREZ, GEORGINA CARCIOFI BOYERO - HOSPITAL DE NIñOS RICARDO GUTIÉRREZ, NATACHA WEINBERGER - HOSPITAL DE NIñOS RICARDO GUTIÉRREZ, ANA MARÍA GÓMEZ SALDAñO - MINISTRY OF HEALTH, CARLA ALPIRE ALPONTE - MINISTRY OF HEALTH, PATRICIA AUZA ALARCÓN - MINISTRY OF HEALTH, AYELÉN COPA TARQUI - MINISTRY OF HEALTH, SHEILA CORTEZ - MINISTRY OF HEALTH, PAMELA GALLARDO - MINISTRY OF HEALTH, JANETH GEMIO PINAYA - MINISTRY OF HEALTH, ÁNGELES HERNANDEZ NAVARRO - MINISTRY OF HEALTH, ALEJANDRO MACCIO - MINISTRY OF HEALTH, PAULA MOSQUEDA - MINISTRY OF HEALTH, NICOLE NEME - MINISTRY OF HEALTH, BANIA QUISPE - MINISTRY OF HEALTH, EMILIO RAMÍREZ BERNA - MINISTRY OF HEALTH, THELMA SORIA - MINISTRY OF HEALTH, ANGÉLICA FERNÁNDEZ ARCE - MINISTRY OF HEALTH, ANDREA GAMARNIK - INSTITUTO LELOIR- CONICET, FERNÁN GONZÁLEZ BERNALDO DE QUIRÓS - MINISTRY OF HEALTH
The durability of the antibody response following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections has not been fully elucidated. We have performed a cross-sectional study in one of the largest slums of Buenos Aires, Barrio Padre Mugica in June 2020, detecting a seroprevalence of 53.4%. To evaluate the persistence of the humoral response against SARS-CoV-2 in this area, we designed a second study assessing only the people that were IgG positive in the first survey. The IgG levels against the full spike (S) protein in 175 individuals that were seropositive, at least 6 months before, were evaluated in a second survey. The positivity rate was 92.0%, 161 from 175 individuals remained IgG positive. We observed a contraction in the overall IgG levels measured by ELISA. The median IgG dropped 62% from June to December 2020. Most of the individuals tested (87%) reported to be asymptomatic or oligo-symptomatic. No difference was found between men and women, but people aged less than 50 showed a lower IgG level in each period compared to older individuals. Our data indicate sustained humoral immunity for at least 6 months in a specific socio-economical setting in a population that was mainly asymptomatic for COVID-19.
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